HIPPOCAMPAL OXYTOCIN MEDIATES APOMORPHINE-INDUCED PENILE ERECTION AND YAWNING

被引:73
作者
MELIS, MR [1 ]
STANCAMPIANO, R [1 ]
ARGIOLAS, A [1 ]
机构
[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY
关键词
APOMORPHINE; OXYTOCIN; PENILE ERECTION; YAWNING; RAT;
D O I
10.1016/0091-3057(92)90447-N
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Repeated episodes of penile erection and yawning can be induced in male rats either by low doses of the dopaminergic agonist apomorphine or by oxytocin given systematically or into a lateral ventricle (ICV), respectively, or after microinjection of the two substances directly in the paraventricular nucleus (PVN) of the hypothalamus. These behavioral responses are prevented in a dose-dependent manner by the ICV administration of the potent oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin. In contrast, the PVN injection of d(CH2)5Tyr(Me)-Orn8-vasotocin (1-30 ng), while effective in preventing oxytocin effect, was unable to prevent apomorphine response. On the other hand, apomorphine-, but not oxytocin-induced penile erection and yawning was prevented by electrolytic lesion of the medial septum (MS). Such a lesion decreased oxytocin content by about 45% in the hippocampus. The above results suggest that the hypothalamic-hippocampal oxytocinergic pathway mediates apomorphine-induced penile erection and yawning and that oxytocin is involved at different levels in the CNS for the control of these behavioral responses.
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页码:61 / 66
页数:6
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