CGP-55845A - A POTENT ANTAGONIST OF GABA(B) RECEPTORS IN THE CA1 REGION OF RAT HIPPOCAMPUS

被引：101

作者：

DAVIES, CH ^{[1
]}

POZZA, MF ^{[1
]}

COLLINGRIDGE, GL ^{[1
]}

机构：

[1] CIBA GEIGY AG,DEPT RES & DEV,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 10期

关键词：

GAMMA-AMINOBUTYRIC ACID; CGP; 55845A; GABA-B; RECEPTOR; HETEROSYNAPTIC DEPRESSION; HIPPOCAMPUS; PAIRED-PULSE DEPRESSION;

D O I：

10.1016/0028-3908(93)90073-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The new GABA(B) receptor antagonist CGP 55845A was tested on pre- and post-synaptic GABA(B) receptors in the hippocampus. CGP55845A (1 muM) blocked (-)-baclofen (5-10 muM)-induced postsynaptic hyperpolarization and depression of evoked IPSPs and EPSPs. It also blocked three physiological consequences of GABA(B) receptor activation: the late IPSP, paired-pulse depression of IPSCs, and heterosynaptic depression of EPSPs. Therefore, CGP55845A is an antagonist at pre- and post-synaptic GABA(B) receptors in the hippocampus and is approximately three orders of magnitude mom potent than previously described GABA(B) receptor antagonists.

引用

页码：1071 / 1073

页数：3

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