LOCAL EXPRESSION OF ANTIINFLAMMATORY CYTOKINES IN CANCER

被引:187
作者
YAMAMURA, M
MODLIN, RL
OHMEN, JD
MOY, RL
机构
[1] UNIV CALIF LOS ANGELES,SCH MED,DIV DERMATOL,200 UCLA MED PLAZA,SUITE 465,LOS ANGELES,CA 90024
[2] VET ADM MED CTR,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,JONSSON COMPREHENS CANC CTR,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024
关键词
BASAL CELL CARCINOMA; CYTOKINES; T-LYMPHOCYTES; INTERLEUKIN-4; INTERLEUKIN-10;
D O I
10.1172/JCI116256
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
To characterize the nature of the local cytokine response to cancer, we chose to investigate cytokine patterns in biopsy specimens of basal cell carcinoma (BCC). We hypothesized that a distinct pattern of local cytokine production may be characteristic of BCC, a neoplasia of epidermis, in comparison to the pattern of seborrheic keratosis (SK), a benign growth of epidermis. We analyzed cytokine mRNAs in BCC versus SK by performing polymerase chain reaction on mRNA derived from biopsy specimens. The mRNAs encoding cytokines for IL-4, IL-5, IL-10, and granulocyte macrophage colony-stimulating factor were strongly expressed in BCC lesions and weakly expressed in SK lesions. Conversely, IL-2, IFN-gamma, and lymphotoxin mRNAs were strongly expressed in SK lesions and weakly expressed in BCC lesions. The response to malignancy, BCC, was typified by cytokines characteristic of murine T(H)2 cells. This cytokine pattern favors humoral immunity with concomitant immunosuppression of cell-mediated immune responses. In comparison, the response to the benign growth, SK, was typified by cytokines characteristic of murine T(H)1 cells that favor cell-mediated immune reactions. The findings of a distinct cytokine pattern in skin cancer provide a framework to develop strategies for immunologic intervention.
引用
收藏
页码:1005 / 1010
页数:6
相关论文
共 38 条
[1]  
BELLDEGRUN A, 1989, J IMMUNOL, V142, P4520
[2]   CROSS-LINKING FC-RECEPTORS STIMULATE SPLENIC NON-B, NON-T CELLS TO SECRETE INTERLEUKIN-4 AND OTHER LYMPHOKINES [J].
BENSASSON, SZ ;
LEGROS, G ;
CONRAD, DH ;
FINKELMAN, FD ;
PAUL, WE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1421-1425
[3]   REVISITING AND REVISING SUPPRESSOR T-CELLS [J].
BLOOM, BR ;
SALGAME, P ;
DIAMOND, B .
IMMUNOLOGY TODAY, 1992, 13 (04) :131-136
[4]   INTRALESIONAL INTERFERON THERAPY FOR BASAL-CELL CARCINOMA [J].
CORNELL, RC ;
GREENWAY, HT ;
TUCKER, SB ;
EDWARDS, L ;
ASHWORTH, S ;
VANCE, JC ;
TANNER, DJ ;
TAYLOR, EL ;
SMILES, KA ;
PEETS, EA .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 23 (04) :694-700
[5]  
CURSON C, 1979, J CUTAN PATHOL, V6, P432, DOI 10.1111/j.1600-0560.1979.tb01166.x
[6]  
DUPPER T, 1987, J IMMUNOL, V136, P4288
[7]   IL-1 AND IL-4 AS RECIPROCAL REGULATORS OF IL-2 INDUCED LYMPHOCYTE CYTOTOXICITY [J].
EBINA, N ;
GALLARDO, D ;
SHAU, H ;
GOLUB, SH .
BRITISH JOURNAL OF CANCER, 1990, 62 (04) :619-623
[8]  
ENK AH, 1992, J IMMUNOL, V149, P92
[9]   INTERLEUKIN-2 PRODUCTION BY TUMOR-CELLS BYPASSES T-HELPER FUNCTION IN THE GENERATION OF AN ANTITUMOR RESPONSE [J].
FEARON, ER ;
PARDOLL, DM ;
ITAYA, T ;
GOLUMBEK, P ;
LEVITSKY, HI ;
SIMONS, JW ;
KARASUYAMA, H ;
VOGELSTEIN, B ;
FROST, P .
CELL, 1990, 60 (03) :397-403
[10]  
GAJEWSKI TF, 1991, J IMMUNOL, V146, P1750