DIETARY FUMONISIN B-1 INDUCES DISRUPTION OF SPHINGOLIPID METABOLISM IN SPRAGUE-DAWLEY RATS - A NEW MECHANISM OF NEPHROTOXICITY

被引：178

作者：

RILEY, RT ^{[1
]}

HINTON, DM ^{[1
]}

CHAMBERLAIN, WJ ^{[1
]}

BACON, CW ^{[1
]}

WANG, E ^{[1
]}

MERRILL, AH ^{[1
]}

VOSS, KA ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT BIOCHEM,ATLANTA,GA 30322

来源：

JOURNAL OF NUTRITION | 1994年 / 124卷 / 04期

关键词：

FUMONISINS; KIDNEY; RATS; FUSARIUM; SPHINGOLIPIDS;

D O I：

10.1093/jn/124.4.594

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Fumonisins are potent inhibitors of sphingolipid biosynthesis produced by several Fusarium species. Consumption of corn or corn products infected with F. moniliforme, or high levels of fumonisins, is associated with several animal diseases. In a 4-wk feeding study, the concentration of fumonisin B-1 that caused nephrotoxicity in Sprague-Dawley rats was much less than that required to cause hepatotoxicity. This retrospective study shows a close correlation between the extent and severity of ultrastructural lesions and the degree of disruption of sphingolipid metabolism. The kidney was more sensitive to fumonisin B-1-induced disruption of sphingolipid metabolism than liver with significant elevation of free sphingosine, free sphinganine, and the free sphinganine:free sphingosine ratio in rats fed 15, 50 and 150 mu g/g fumonisin B-1. Accumulation of free sphinganine and elevation of the free sphinganine: free sphingosine ratio in urine closely reflected the changes that occurred in kidney. The accumulated sphinganine and elevation of the free sphinganine:free sphingosine ratio was associated with accumulation of cells in urine. Thus, urine rather than serum is the fluid of choice for detecting elevated free sphingoid bases generated as a consequence of fumonisin-induced kidney damage.

引用

页码：594 / 603

页数：10

共 36 条

[1] STRUCTURE ELUCIDATION OF THE FUMONISINS, MYCOTOXINS FROM FUSARIUM-MONILIFORME [J].