C-FOS EXPRESSION MEDIATED BY N-METHYL-D-ASPARTATE RECEPTORS FOLLOWING ANODAL POLARIZATION IN THE RAT-BRAIN

被引:21
作者
ISLAM, N
MORIWAKI, A
HATTORI, Y
HAYASHI, Y
LU, YF
HORI, Y
机构
[1] Department of Physiology, Okayama University Medical School, Okamaya 700
关键词
D O I
10.1006/exnr.1995.1004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in c-Fos protein-like IR in neurons of the cingulate, piriform, frontoparietal cortices, and hippocampus ipsilateral to the polarization. The effects were dependent upon the duration and intensity of currents applied. The time-dependent induction of c-Fos protein-like IR was maximal at 1 h, became weaker by 6 h, and almost returned to the baseline within 24 h following polarization. When MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-im hydrogen maleate], a noncompetitive antagonist for N-methyl-D-aspartate (NMDA) receptors, was injected intraperitoneally, the induction of this nuclear protein was reduced or completely blocked in both hemispheres, except around the polarized point itself, as a function of the time and dosage. These results suggest that the proto-oncogene c-fos is rapidly and transiently activated in the brain following anodal polarization and this activation is mediated by NMDA receptors. (C) 1995 Academic Press,
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页码:25 / 31
页数:7
相关论文
共 37 条
[1]   ACTION OF BRIEF POLARIZING CURRENTS ON CEREBRAL CORTEX OF RAT .1. DURING CURRENT FLOW + .2. IN PRODUCTION OF LONG-LECTING AFTER-EFFECTS [J].
BINDMAN, LJ ;
LIPPOLD, OCJ ;
REDFEARN, JW .
JOURNAL OF PHYSIOLOGY-LONDON, 1964, 172 (03) :369-&
[2]  
BINDMAN LJ, 1962, NATURE, V162, pP45
[3]  
BINDMAN LJ, 1962, NATURE, V40, P584
[4]  
BRAZOVSKAYA F A, 1972, Neurophysiology, V4, P194
[5]   ONCOGENES, PROTEIN KINASE-C, NEURONAL DIFFERENTIATION AND MEMORY [J].
CHIARUGI, VP ;
RUGGIERO, M ;
CORRADETTI, R .
NEUROCHEMISTRY INTERNATIONAL, 1989, 14 (01) :1-9
[6]   RAPID INCREASE OF AN IMMEDIATE EARLY GENE MESSENGER-RNA IN HIPPOCAMPAL-NEURONS BY SYNAPTIC NMDA RECEPTOR ACTIVATION [J].
COLE, AJ ;
SAFFEN, DW ;
BARABAN, JM ;
WORLEY, PF .
NATURE, 1989, 340 (6233) :474-476
[7]   LONG-TERM POTENTIATION AND THE INDUCTION OF C-FOS MESSENGER-RNA AND PROTEINS IN THE DENTATE GYRUS OF UNANESTHETIZED RATS [J].
DRAGUNOW, M ;
ABRAHAM, WC ;
GOULDING, M ;
MASON, SE ;
ROBERTSON, HA ;
FAULL, RLM .
NEUROSCIENCE LETTERS, 1989, 101 (03) :274-280
[8]   MK-801, AN ANTAGONIST OF NMDA RECEPTORS, INHIBITS INJURY-INDUCED C-FOS PROTEIN ACCUMULATION IN RAT-BRAIN [J].
DRAGUNOW, M ;
FAULL, RLM ;
JANSEN, KLR .
NEUROSCIENCE LETTERS, 1990, 109 (1-2) :128-133
[9]   IMMEDIATE-EARLY GENES, KINDLING AND LONG-TERM POTENTIATION [J].
DRAGUNOW, M ;
CURRIE, RW ;
FAULL, RLM ;
ROBERTSON, HA ;
JANSEN, K .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1989, 13 (04) :301-313
[10]   LOCALIZATION AND INDUCTION OF C-FOS PROTEIN-LIKE IMMUNOREACTIVE MATERIAL IN THE NUCLEI OF ADULT MAMMALIAN NEURONS [J].
DRAGUNOW, M ;
ROBERTSON, HA .
BRAIN RESEARCH, 1988, 440 (02) :252-260