LINKAGE OF OPEN EYELIDS WITH LINKAGE GROUP 7 OF MOUSE

Open eyelids (oe) was described first by Mackensen6. The condition is caused by a single, autosomal, recessive gene. At 16 to 17 days of gestation there is a slight protrusion of the lens into the anterior chamber accompanied, in some cases, by folding of the retina. Young are born with eyelids open and, as adults, have opaque areas in the corneas. Linkage tests were run with various marker genes. Maximum likelihood methods were used for the detection and estimation of linkage. In many cases, segregation ratios of one or both genes in two-point tests were disturbed. Data from such cases were treated by appropriate methods. To eliminate the possibility that the disturbed ratios were produced by differential viability after birth, only litters in which there was no loss between birth and classification were used in estimation of linkage with linkage group VII marker genes. In backcross matings there Mere no statistical differences in data from heterozygous males and heterozygous females; therefore, the data were combined. © 1968, Oxford University Press. All rights reserved.