SYNTHESIS OF CHOLESTERYL ESTERS OF LABELED FATTY-ACIDS

被引:18
作者
GROVER, AK [1 ]
CUSHLEY, RJ [1 ]
机构
[1] SIMON FRASER UNIV,DEPT CHEM,BURNABY V5A 1S6,BC,CANADA
关键词
1,1′‐Carbonyl‐diimidazole; Carbon‐14; Cholesteryl Palmitate; Deuterium; Spin Labels;
D O I
10.1002/jlcr.2580160210
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Cholesteryl esters of variously labelled fatty acids have been synthesized in high yield by 1,1′‐carbonyldiimidazole activation of the acyl group and reaction of the resulting acylimidazole derivative with cholesterol. The method has been used to synthesize cholesteryl esters on micro and semimicro scales. Syntheses of the following esters are reported: cholesteryl palmitate‐1‐14C, cholesteryl palmitate‐d31, cholesteryl palmitate‐2,2‐d2, cholesteryl palmitate‐d31, cholesteryl palmitate‐2,2‐d2, cholesteryl palmitate‐3,3,4,4,5,5,6,6,7,7,8,8,9,9,‐10,10,11,11,12,12,13,13,14,14,15,15,16,16,16‐d29, cholesteryl 5‐doxylpalmitate and cholesteryl 16‐doxylstearate. Copyright © 1979 John Wiley & Sons, Ltd.
引用
收藏
页码:307 / 313
页数:7
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