INVITRO RESTORATION BY LEVAMISOLE OF MITOGEN RESPONSIVENESS IN ZINC-DEPRIVED RATS .2.

被引：21

作者：

GROSS, RL ^{[1
]}

OSDIN, N ^{[1
]}

FONG, L ^{[1
]}

NEWBERNE, PM ^{[1
]}

机构：

[1] MIT, DEPT NUTR & FOOD SCI, CAMBRIDGE, MA 02139 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1979年 / 32卷 / 06期

关键词：

D O I：

10.1093/ajcn/32.6.1267

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of levamisole on the in vitro responses of splenic and peripheral blood lymphocytes to phytohemagglutinin was investigated in zinc-deprived and pair-fed control rats. The in vitro response of lymphocytes from zinc-deprived rats was markedly impaired in comparison with that of controls. The addition of levamisole to cultures of zinc-deprived splenic lymphocytes significantly improved their response to phytohemagglutinin by 54%. The addition of levamisole to cultures of zinc-deprived peripheral blood lymphocytes significantly improved their response by 116.2%. The addition of levamisole to control lymphocyte cultures had no effect. This study may be the first to evaluate the beneficial effect of an immunomodulating agent on immune function in a nutritionally deprived host.

引用

页码：1267 / 1271

页数：5

共 37 条

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[10] DEPRESSED IMMUNOLOGICAL FUNCTION IN ZINC-DEPRIVED RATS AS MEASURED BY MITOGEN RESPONSE OF SPLEEN, THYMUS, AND PERIPHERAL-BLOOD .1.
GROSS, RL
OSDIN, N
FONG, L
NEWBERNE, PM
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1979, 32 (06) : 1260 - 1266

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