INVITRO RESTORATION BY LEVAMISOLE OF MITOGEN RESPONSIVENESS IN ZINC-DEPRIVED RATS .2.

被引:21
作者
GROSS, RL [1 ]
OSDIN, N [1 ]
FONG, L [1 ]
NEWBERNE, PM [1 ]
机构
[1] MIT, DEPT NUTR & FOOD SCI, CAMBRIDGE, MA 02139 USA
关键词
D O I
10.1093/ajcn/32.6.1267
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The effect of levamisole on the in vitro responses of splenic and peripheral blood lymphocytes to phytohemagglutinin was investigated in zinc-deprived and pair-fed control rats. The in vitro response of lymphocytes from zinc-deprived rats was markedly impaired in comparison with that of controls. The addition of levamisole to cultures of zinc-deprived splenic lymphocytes significantly improved their response to phytohemagglutinin by 54%. The addition of levamisole to cultures of zinc-deprived peripheral blood lymphocytes significantly improved their response by 116.2%. The addition of levamisole to control lymphocyte cultures had no effect. This study may be the first to evaluate the beneficial effect of an immunomodulating agent on immune function in a nutritionally deprived host.
引用
收藏
页码:1267 / 1271
页数:5
相关论文
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