RADIORECEPTOR ASSAY FOR DIAZEPAM AND ITS METABOLITES IN SERUM

被引：25

作者：

OWEN, F

LOFTHOUSE, R

BOURNE, RC

机构：

[1] Division of Psychiatry, Clinical Research Centre, Watford Road

来源：

CLINICA CHIMICA ACTA | 1979年 / 93卷 / 03期

关键词：

D O I：

10.1016/0009-8981(79)90279-1

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A radioreceptor method is described for the estimation of serum concentrations of diazepam and its metabolites. The technique is simple, rapid and suitable for batch analysis. An advantage of the technique is that it gives a measure of the total pharmacological activity of the serum samples towards the benzodiazepine receptor and is thus directly applicable to benzodiazepines other than diazepam. The results obtained by the radioreceptor assay and by a GLC technique are correlated. © 1979.

引用

页码：305 / 310

页数：6

共 19 条

[1]

BOURNE RC, 1978, BRIT J PHARMACOL, V63, pP371

[2] BRAIN SPECIFIC BENZODIAZEPINE RECEPTORS [J].