A SYNTHESIS OF (+)-7-EPIAUSTRALINE AND (-)-7-EPIALEXINE

被引：54

作者：

PEARSON, WH ^{[1
]}

HINES, JV ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT MED CHEM,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 40期

关键词：

(+)-7-EPIAUSTRALINE; (-)-7-EPIALEXINE; GLYCOSIDASE INHIBITORS; POLYHYDROXYLATED PYRROLIZIDINE ALKALOIDS; EPOXIDE;

D O I：

10.1016/0040-4039(91)80071-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive cyclization of the azido epoxides 19-alpha and 19-beta followed by deprotection afforded the HIV inhibitor (+)-7-epiaustraline 7 and (-)-7-epialexine 9. The formation of 7 proceeded with an unusual inversion of configuration at C-7.

引用

页码：5513 / 5516

页数：4

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