NIGROSTRIATAL PATHWAY MODULATES STRIATUM VULNERABILITY TO QUINOLINIC ACID

被引：31

作者：

BUISSON, A

PATEAU, V

PLOTKINE, M

BOULU, RG

机构：

[1] Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris

来源：

NEUROSCIENCE LETTERS | 1991年 / 131卷 / 02期

关键词：

QUINOLINIC ACID; STRIATUM; DOPAMINE; SUBSTANTIA-NIGRA;

D O I：

10.1016/0304-3940(91)90627-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nigrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.

引用

页码：257 / 259

页数：3

共 17 条

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