HLA-DPB1-STAR-0301 IS A MAJOR RISK FACTOR FOR RHEUMATOID-FACTOR NEGATIVE ADULT RHEUMATOID-ARTHRITIS

被引：31

作者：

GAO, XJ

FERNANDEZVINA, M

OLSEN, NJ

PINCUS, T

STASTNY, P

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,5323 HARRY HINES BLVD,DALLAS,TX 75235

[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT MED,DIV RHEUMATOL & IMMUNOL,NASHVILLE,TN 37232

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 10期

关键词：

D O I：

10.1002/art.1780341016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HLA-DPB1 alleles were determined using the polymerase chain reaction and allele-specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticular-onset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

引用

收藏

页码：1310 / 1312

页数：3

相关论文

共 13 条

[1] A SPECIFIC HLA-DP-BETA ALLELE IS ASSOCIATED WITH PAUCIARTICULAR JUVENILE RHEUMATOID-ARTHRITIS BUT NOT ADULT RHEUMATOID-ARTHRITIS [J].

BEGOVICH, AB ;

BUGAWAN, TL ;

NEPOM, BS ;

KLITZ, W ;

NEPOM, GT ;

ERLICH, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9489-9493

[2] DNA TYPING FOR CLASS-II HLA ANTIGENS WITH ALLELE-SPECIFIC OR GROUP-SPECIFIC AMPLIFICATION .3. TYPING FOR 24 ALLELES OF HLA-DP [J].

FERNANDEZVINA, M ;

MORAES, ME ;

STASTNY, P .

HUMAN IMMUNOLOGY, 1991, 30 (01) :60-68

[3] HLA ANTIGENS IN JUVENILE ARTHRITIS - PAUCIARTICULAR AND POLYARTICULAR JUVENILE ARTHRITIS ARE IMMUNOGENETICALLY DISTINCT [J].

FERNANDEZVINA, MA ;

FINK, CW ;

STASTNY, P .

ARTHRITIS AND RHEUMATISM, 1990, 33 (12) :1787-1794

[4] DNA TYPING FOR CLASS-II HLA ANTIGENS WITH ALLELE-SPECIFIC OR GROUP-SPECIFIC AMPLIFICATION .1. TYPING FOR SUBSETS OF HLA-DR4 [J].

GAO, XJ ;

FERNANDEZVINA, M ;

SHUMWAY, W ;

STASTNY, P .

HUMAN IMMUNOLOGY, 1990, 27 (01) :40-50

[5]

MITSUISHI Y, 1987, IMMUNOBIOLOGY HLA, V1

[6] SPECIFIC HLA-DR4-ASSOCIATED HISTOCOMPATIBILITY MOLECULES CHARACTERIZE PATIENTS WITH SEROPOSITIVE JUVENILE RHEUMATOID-ARTHRITIS [J].

NEPOM, BS ;

NEPOM, GT ;

MICKELSON, E ;

SCHALLER, JG ;

ANTONELLI, P ;

HANSEN, JA .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (01) :287-291

[7]

NUNEZ G, 1984, J RHEUMATOL, V11, P129

[8] ASSOCIATIONS OF HLA-DR4 WITH RHEUMATOID-FACTOR AND RADIOGRAPHIC SEVERITY IN RHEUMATOID-ARTHRITIS [J].

OLSEN, NJ ;

CALLAHAN, LF ;

BROOKS, RH ;

NANCE, EP ;

KAYE, JJ ;

STASTNY, P ;

PINCUS, T .

AMERICAN JOURNAL OF MEDICINE, 1988, 84 (02) :257-264

[9]

ROPES M W, 1958, Bull Rheum Dis, V9, P175

[10] EVIDENCE FOR A NEW SEGREGANT SERIES OF B-CELL ANTIGENS THAT ARE ENCODED IN THE HLA-D REGION AND THAT STIMULATE SECONDARY ALLOGENEIC PROLIFERATIVE AND CYTO-TOXIC RESPONSES [J].

SHAW, S ;

JOHNSON, AH ;

SHEARER, GM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 152 (03) :565-580