WATER BASED SILICONE ELASTOMER CONTROLLED RELEASE TABLET FILM COATING .6. THE EFFECT OF TABLET SHAPE

被引：6

作者：

LI, LC ^{[1
]}

PECK, GE ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT IND & PHYS PHARM,W LAFAYETTE,IN 47907

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 03期

关键词：

D O I：

10.3109/03639049209043703

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The silicone elastomer latex containing colloidal silica and polyoxyethylene glycol 8,000 was shown to produce controlled released film coating on potassium chloride tablets with different shapes. The tablet shape did not affect the zero-order release characteristic of the active ingredient from the coated tablets. With the same coating weight, the capsule shaped tablets exhibited a faster drug release rate as compared to the oval and round deep-cup shaped tablets.

引用

页码：333 / 343

页数：11

共 4 条

[1] WATER BASED SILICONE ELASTOMER CONTROLLED RELEASE TABLET FILM COATING .1. FREE FILM EVALUATION [J].

LI, LC ;

PECK, GE .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (01) :65-95

[2] WATER BASED SILICONE ELASTOMER CONTROLLED RELEASE TABLET FILM COATING .3. DRUG RELEASE MECHANISMS [J].

LI, LC ;

PECK, GE .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (12) :1943-1968

[3] WATER BASED SILICONE ELASTOMER CONTROLLED RELEASE TABLET FILM COATING-II - FORMULATION CONSIDERATIONS AND COATING EVALUATION [J].

LI, LC ;

PECK, GE .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (04) :499-531

[4]

NETER J, 1985, APPLIED LINEAR STATI

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