TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 10-DEOXYTAXOL

被引：44

作者：

CHEN, SH

FAIRCHILD, C

MAMBER, SW

FARINA, V

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492-7660

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 11期

关键词：

D O I：

10.1021/jo00063a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group. Compound 2 was found to possess comparable antitumor activity with respect to taxol. This confirms that the functional group at C-10 in taxol is not involved in receptor binding. © 1993, American Chemical Society. All rights reserved.

引用

页码：2927 / 2928

页数：2

共 8 条

[1]

CHEN SH, IN PRESS TETRAHEDRON

[2] THE CHEMISTRY OF TAXOL [J].