TSH RESPONSES TO TRH AS A FUNCTION OF BASAL SERUM TSH - RELEVANCE FOR UNIPOLAR DEPRESSION IN FEMALES - A MULTIVARIATE STUDY

被引:21
作者
MAES, M
SCHOTTE, C
VANDEWOUDE, M
MARTIN, M
BLOCKX, P
机构
[1] UNIV INSTELLING ANTWERP,DEPT PSYCHIAT,B-2610 WILRIJK,BELGIUM
[2] UNIV INSTELLING ANTWERP,DEPT INTERNAL MED,B-2610 WILRIJK,BELGIUM
[3] UNIV INSTELLING ANTWERP,DEPT DIABET & DIETET,B-2610 WILRIJK,BELGIUM
关键词
D O I
10.1055/s-2007-1014394
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Baseline thyroid-secreting-hormone (TSH) - assessed by means of ultrasensitive assays (IRMA) - and free-thyroid-hormone (FT4) levels were determined in 84 depressed females, and the TSH responses to 200-mu-g thyrotropin-releasing hormone (TRH) (IV) measured. It was found that TRH-induced TSH responses were linearly and positively related to basal TSH-IRMA; lower TRH-stimulated TSH secretion in melancholic patients was attributable to lowered basal TSH-IRMA values. A progression was found - within the euthyroid range - of basal TSH-IRMA values towards lower levels along the diagnostic spectrum: the highest basal TSH-IRMA levels were witnessed in minor depressives and the lowest in melancholics, while simple major-depressed females occupied an intermediate position. This shift appears to be indicative of severity of illness. Basal TSH-IRMA data can roughly be used as a clinical tool separating melancholia from minor depression: at a threshold value of less-than-or-equal-to 1-mu-UI-ml, sensitivity was 56% and specificity 92%. It is concluded that basal TSH-IRMA provides a more accurate representation of melancholia than peak TSH responses, which appear to constitute little more than a magnified, but biased signal of basal TSH-IRMA. In future, the assay of basal TSH-IRMA could replace TRH testing.
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页码:136 / 144
页数:9
相关论文
共 49 条
[1]   THE HYPOTHALAMIC-PITUITARY-THYROID AXIS IN PSYCHIATRIC-PATIENTS AND HEALTHY-SUBJECTS .1.4. [J].
BAUMGARTNER, A ;
GRAF, KJ ;
KURTEN, I ;
MEINHOLD, H .
PSYCHIATRY RESEARCH, 1988, 24 (03) :271-332
[2]  
BLOCKX P, 1987, THYROTROPIN ULTRASEN, P145
[3]  
BOTTGER IG, 1987, THYROTROPIN ULTRASEN, P219
[4]  
BRETZEL RG, 1987, THYROTROPIN ULTRASEN, P251
[5]   ENDOCRINE CHANGES AND CLINICAL PROFILES IN DEPRESSION .2. THE THYROTROPIN-RELEASING-HORMONE TEST [J].
CALLOWAY, SP ;
DOLAN, RJ ;
FONAGY, P ;
DESOUZA, VFA ;
WAKELING, A .
PSYCHOLOGICAL MEDICINE, 1984, 14 (04) :759-765
[6]   EXTRACTION OF INFORMATION FROM LARGE DATA SETS BY PATTERN-RECOGNITION [J].
DERDE, MP ;
MASSART, DL .
FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1982, 313 (06) :484-495
[7]  
DERDE MP, 1984, J ASSOC OFF ANA CHEM, V67, P721
[8]  
DEWHURST KE, 1968, CONFIN NEUROL, V30, P161
[9]  
DILLON WR, 1984, MULTIVARIATE ANAL ME, P430
[10]   THE THYROTROPIN-RELEASING-HORMONE TEST IN THE DIAGNOSIS OF UNIPOLAR DEPRESSION [J].
EXTEIN, I ;
POTTASH, ALC ;
GOLD, MS .
PSYCHIATRY RESEARCH, 1981, 5 (03) :311-316