BIOTRANSFORMATIONS BY MICROBIAL BAEYER-VILLIGER MONOOXYGENASES STEREOSELECTIVE LACTONE FORMATION INVITRO BY COUPLED ENZYME-SYSTEMS

被引：30

作者：

GROGAN, G

ROBERTS, S

WILLETTS, A

机构：

[1] UNIV EXETER,DEPT BIOL SCI,EXETER EX4 4QG,DEVON,ENGLAND

[2] UNIV EXETER,DEPT BIOL SCI,DEPT CHEM,EXETER EX4 4QG,DEVON,ENGLAND

来源：

BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 12期

关键词：

D O I：

10.1007/BF01027014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The regio- and stereoselective biotransformation of bicyclo(3.2.0)hept-2-en-6-one by the NADH-dependent Baeyer-Villiger monooxygenase from camphor-grown Pseudomonas putida NCIMB 10007 has been shown to yield a chiral lactone not accessible by currently-used biocatalysts. The biotransformation can be conducted in vitro using two alternative coupled enzyme systems (alcohol dehydrogenase and monooxygenase: formate dehydrogenase and monooxygenase) with in situ recycling of NAD+/NADH.

引用

页码：1125 / 1130

页数：6

共 17 条

[1] MICROBIOLOGICAL TRANSFORMATIONS .22. MICROBIOLOGICALLY MEDIATED BAEYER-VILLIGER REACTIONS - A UNIQUE ROUTE TO SEVERAL BICYCLIC GAMMA-LACTONES IN HIGH ENANTIOMERIC PURITY
ALPHAND, V
FURSTOSS, R
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (04) : 1306 - 1309
[2] MICROBIAL TRANSFORMATIONS .16. ONE-STEP SYNTHESIS OF A PIVOTAL PROSTAGLANDIN CHIRAL SYNTHON VIA A HIGHLY ENANTIOSELECTIVE MICROBIOLOGICAL BAEYER-VILLIGER TYPE REACTION
ALPHAND, V
ARCHELAS, A
FURSTOSS, R
[J]. TETRAHEDRON LETTERS, 1989, 30 (28) : 3663 - 3664
[3] ALPHAND V, 1990, BIOCATALYSIS, V3, P73
[4] BIOTRANSFORMATIONS BY FUNGI - REGIOSELECTIVE PLUS STEREOSELECTIVE BAEYER-VILLIGER OXIDATIONS BY DEMATIACEOUS FUNGI
CARNELL, A
WILLETTS, A
[J]. BIOTECHNOLOGY LETTERS, 1992, 14 (01) : 17 - 20
[5] ENZYME-CATALYZED BAEYER-VILLIGER OXIDATIONS OF SOME SUBSTITUTED BICYCLO[3.2.0]HEPTANONES
CARNELL, AJ
ROBERTS, SM
SIK, V
WILLETTS, AJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (20) : 1438 - 1439
[6] MICROBIAL OXIDATION OF 7ENDO-METHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE, 7,7-DIMETHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE AND 2EXO-BROMO-3ENDO-HYDROXY-7,7-DIMETHYLBICYCLO[3.2.0]HEPTAN-6-ONE USING ACINETOBACTER NCIMB-9871
CARNELL, AJ
ROBERTS, SM
SIK, V
WILLETTS, AJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (10): : 2385 - 2389
[7] METABOLISM OF CYCLOPENTANOL BY PSEUDOMONAS NCIB-9872
GRIFFIN, M
TRUDGILL, PW
[J]. BIOCHEMICAL JOURNAL, 1972, 129 (03) : 595 - &
[8] ENZYMES IN ORGANIC-SYNTHESIS
JONES, JB
[J]. TETRAHEDRON, 1986, 42 (13) : 3351 - 3403
[9] LEVITT MS, 1990, J CHEM SOC CHEM COMM
[10] CAMPHOR REVISITED - INVOLVEMENT OF A UNIQUE MONOOXYGENASE IN METABOLISM OF 2-OXO-DELTA-3-4,5,5-TRIMETHYLCYCLOPENTENYLACETIC ACID BY PSEUDOMONAS-PUTIDA
OUGHAM, HJ
TAYLOR, DG
TRUDGILL, PW
[J]. JOURNAL OF BACTERIOLOGY, 1983, 153 (01) : 140 - 152

← 1 2 →