SARASINOSIDES D-G - 4 NEW TRITERPENOID SAPONINS FROM THE SPONGE ASTEROPUS-SARASINOSUM

被引：34

作者：

ESPADA, A

JIMENEZ, C

RODRIGUEZ, J

CREWS, P

RIGUERA, R

机构：

[1] UNIV SANTIAGO COMPOSTELA, FAC QUIM, DEPT QUIM ORGAN, E-15706 SANTIAGO, SPAIN

[2] UNIV A CORUNA, FAC CIENCIAS, DEPT QUIM FUNDAMENTAL & IND, E-15071 CORUNA, SPAIN

[3] UNIV CALIF SANTA CRUZ, DEPT CHEM & BIOCHEM, SANTA CRUZ, CA 95064 USA

来源：

TETRAHEDRON | 1992年 / 48卷 / 40期

关键词：

D O I：

10.1016/S0040-4020(01)89444-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new triterpenoid oligoglycosides (2-5; sarasinosides D-G, respectively) and sarasinoside B1 (1) have been isolated from the butanolic extracts of the sponge Asteropus sarasinosum, which showed in vitro cytotoxic activity against several types of tumour cells and inhibition to protein kinase C. These compounds have identical sugar chains and differ in the aglycon moiety. Structures were established by FAB-MS, COSY, XHCORR, RCOSY, TOCSY, ROESY and HMQC experiments, and confirmed by selective hydrolysis and permethylation followed by methanolysis.

引用

页码：8685 / 8696

页数：12

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