BLOCK OF ACETYLCHOLINE-ACTIVATED ION CHANNELS BY AN UNCHARGED LOCAL-ANESTHETIC

被引：95

作者：

OGDEN, DC

SIEGELBAUM, SA

COLQUHOUN, D

机构：

来源：

NATURE | 1981年 / 289卷 / 5798期

关键词：

D O I：

10.1038/289596a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：596 / 598

页数：3

共 18 条

[1] VOLTAGE JUMP ANALYSIS OF PROCAINE ACTION AT FROG ENDPLATE [J].

ADAMS, PR .

JOURNAL OF PHYSIOLOGY-LONDON, 1977, 268 (02) :291-318

[2] DRUG BLOCKADE OF OPEN ENDPLATE CHANNELS [J].

ADAMS, PR .

JOURNAL OF PHYSIOLOGY-LONDON, 1976, 260 (03) :531-552

[3]

COURTNEY KR, 1975, J PHARMACOL EXP THER, V195, P225

[4]

Dreyer F, 1979, Prog Brain Res, V49, P213

[5] EFFECTS OF SOME ALIPHATIC-ALCOHOLS ON CONDUCTANCE CHANGE CAUSED BY A QUANTUM OF ACETYLCHOLINE AT TOAD ENDPLATE [J].

GAGE, PW ;

MCBURNEY, RN ;

SCHNEIDER, GT .

JOURNAL OF PHYSIOLOGY-LONDON, 1975, 244 (02) :409-429

[6] LOCAL-ANESTHETICS - HYDROPHILIC AND HYDROPHOBIC PATHWAYS FOR DRUG-RECEPTOR REACTION [J].

HILLE, B .

JOURNAL OF GENERAL PHYSIOLOGY, 1977, 69 (04) :497-515

[7] EFFECT OF PROCAINE ON ACTION OF ACETYLCHOLINE AT NEUROMUSCULAR-JUNCTION [J].

KATZ, B ;

MILEDI, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1975, 249 (02) :269-284

[8] LIGHT-ACTIVATED DRUG CONFIRMS A MECHANISM OF ION CHANNEL BLOCKADE [J].

LESTER, HA ;

KROUSE, ME ;

NASS, MM ;

WASSERMANN, NH ;

ERLANGER, BF .

NATURE, 1979, 280 (5722) :509-510

[9] QUANTITATIVE DESCRIPTION OF END-PLATE CURRENTS [J].

MAGLEBY, KL ;

STEVENS, CF .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 223 (01) :173-&

[10] NOISE AND RELAXATION STUDIES OF ACETYLCHOLINE INDUCED CURRENTS IN PRESENCE OF PROCAINE [J].

MARTY, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1978, 278 (MAY) :237-250

← 1 2 →