EPITOPES IN THE 19KDA FRAGMENT OF THE PLASMODIUM-FALCIPARUM MAJOR MEROZOITE SURFACE PROTEIN-1 (PFMSP-1(19)) RECOGNIZED BY HUMAN-ANTIBODIES

被引：16

作者：

SHAI, S ^{[1
]}

BLACKMAN, MJ ^{[1
]}

HOLDER, AA ^{[1
]}

机构：

[1] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

PARASITE IMMUNOLOGY | 1995年 / 17卷 / 05期

基金：

英国医学研究理事会;

关键词：

MALARIA; PLASMODIUM FALCIPARUM; ANTIBODY RESPONSE; ELISA;

D O I：

10.1111/j.1365-3024.1995.tb01025.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antibody response to two different epitopes located in the C-terminal 19 kDa fragment of the Plasmodium falciparum merozoite surface protein-1 (MSP-1(19)) has been studied using a competitive ELISA based on the inhibition bf monoclonal antibody (MoAb) binding by serum samples. Sera fi om children aged three to eight years who suffered clinical symptoms of malaria, or were partially immune with an asymptomatic infection, and from adults all living in The Gambia, West Africa were tested. The results suggest that the antibody response to MSP-1(19) has a role in naturally-acquired immunity in Gambian individuals.

引用

页码：269 / 275

页数：7

共 33 条

[1] SECONDARY PROCESSING OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP1) BY A CALCIUM-DEPENDENT MEMBRANE-BOUND SERINE PROTEASE - SHEDDING OF MSP133 AS A NONCOVALENTLY ASSOCIATED COMPLEX WITH OTHER FRAGMENTS OF THE MSP1 [J].