THE ROLE OF PROPIONATE AND ACETATE IN THE CONTROL OF FOOD-INTAKE IN SHEEP

被引:70
作者
FARNINGHAM, DAH
WHYTE, CC
机构
[1] The Rowett Research Institute, Bucksburn, AB2 9SB, Greenburn Road
关键词
FOOD INTAKE; PROPIONATE; SHEEP;
D O I
10.1079/BJN19930103
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Sheep fed ad fib. on a good-quality pelleted diet (g/kg; hav 500, barley 300, molasses, fish meal and minerals) were infused via the hepatic portal vein with mixtures of the sodium salts of volatile fatty acids, acetate and propionate, and a variety of equivalent osmotic loads. Propionate infused at rates between 0.6 and 2.5 mmol/min consistently reduced food intake in a linear, dose-related manner. Propionate infusions resulted in consistent dose-related increases in peripheral venous plasma glucose concentration but variable changes in insulin concentration. Infusion of osmotically balanced mixtures of propionate, acetate, mannitol or saline (9 g NaCl/l) indicated that at constant osmotic loading propionate caused a greater reduction in intake than other infusions. Acetate infusions only depressed food intake when administered as a 1 M solution. Lower concentrations had little effect, similar to that of equivalent osmotic loads of mannitol or saline. It is concluded that portal propionate flow has a potential role in the control of food intake in ruminants which is independent of osmotic effects or changes in plasma insulin concentration.
引用
收藏
页码:37 / 46
页数:10
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