GENETIC-EVIDENCE THAT RI CHLOROQUINE RESISTANCE OF PLASMODIUM-FALCIPARUM IS CAUSED BY RECRUDESCENCE OF RESISTANT PARASITES

被引：53

作者：

BABIKER, H

RANFORDCARTWRIGHT, L

SULTAN, A

SATTI, G

WALLIKER, D

机构：

[1] MINIST HLTH SUDAN,DEPT MALARIA ADM,KHARTOUM,SUDAN

[2] UNIV KHARTOUM,FAC MED,DEPT BIOCHEM,KHARTOUM,SUDAN

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 03期

关键词：

D O I：

10.1016/0035-9203(94)90103-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Isolates of Plasmondium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

引用

页码：328 / 331

页数：4

共 16 条

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