THE ROLE OF PARATHYROID HORMONE-RELATED PROTEIN IN CALCIUM HOMEOSTASIS IN THE FETAL PIG

被引：11

作者：

ABBAS, SK

RATCLIFFE, WA

MONIZ, C

DIXIT, M

CAPLE, IW

SILVER, M

FOWDEN, A

CARE, AD

机构：

[1] UNIV WALES,INST BIOL SCI,ABERYSTWYTH SY23 3DD,DYFED,WALES

[2] QUEEN ELIZABETH MED CTR,WOLFSON RES LABS,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND

[3] UNIV LONDON KINGS COLL HOSP,DEPT CHEM PATHOL,LONDON SE5 9RS,ENGLAND

[4] UNIV MELBOURNE,DEPT VET CLIN SCI,MELBOURNE,VIC 3030,AUSTRALIA

[5] UNIV CAMBRIDGE,PHYSIOL LAB,CAMBRIDGE CB2 3EG,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1994年 / 79卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1113/expphysiol.1994.sp003785

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The concentrations of plasma parathyroid hormone-like bioactivity and parathyroid hormone-related protein (1-86) (PTHrP) immunoreactivity were both higher in fetal pigs than in their mothers during the last 3 weeks of gestation. Both activities changed inversely with alterations in the plasma ionized calcium concentration. The data suggest that PTHrP may have a role in calcium homeostasis in the fetal pig, similar to its postulated role in sheep in the stimulation of calcium transport across the placenta.

引用

页码：527 / 536

页数：10

共 17 条

[11] BIOACTIVITY OF PARATHYROID-HORMONE AND PARATHYROID HORMONE-LIKE PEPTIDE - AGONIST AND ANTAGONIST ACTIVITIES OF AMINO-TERMINAL FRAGMENTS AS ASSESSED BY THE CYTOCHEMICAL BIOASSAY AND INSITU BIOCHEMISTRY [J].