A NEW THIENYLPYRAZOLOQUINOLINE - A POTENT AND ORALLY ACTIVE INVERSE AGONIST TO BENZODIAZEPINE RECEPTORS

被引:18
作者
TAKADA, S [1 ]
SHINDO, H [1 ]
SASATANI, T [1 ]
MATSUSHITA, A [1 ]
EIGYO, M [1 ]
KAWASAKI, K [1 ]
MURATA, S [1 ]
机构
[1] SHIONOGI & CO LTD,SHIONOGI RES LAB,DIV NEUROPHARMACOL,OSAKA 553,JAPAN
关键词
D O I
10.1021/jm00386a002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:454 / 455
页数:2
相关论文
共 14 条
[1]   THE NEUROPHARMACOLOGY OF VARIOUS DIAZEPAM ANTAGONISTS [J].
BOAST, CA ;
BERNARD, PS ;
BARBAZ, BS ;
BERGEN, KM .
NEUROPHARMACOLOGY, 1983, 22 (12B) :1511-1521
[2]   BENZODIAZEPINE RECEPTOR LIGANDS WITH POSITIVE AND NEGATIVE EFFICACY [J].
BRAESTRUP, C ;
NIELSEN, M ;
HONORE, T ;
JENSEN, LH ;
PETERSEN, EN .
NEUROPHARMACOLOGY, 1983, 22 (12B) :1451-1457
[3]   GABA REDUCES BINDING OF H-3-LABELED METHYL BETA-CARBOLINE-3-CARBOXYLATE TO BRAIN BENZODIAZEPINE RECEPTORS [J].
BRAESTRUP, C ;
NIELSEN, M .
NATURE, 1981, 294 (5840) :472-474
[4]   ETHYL BETA-CARBOLINE CARBOXYLATE LOWERS SEIZURE THRESHOLD AND ANTAGONIZES FLURAZEPAM-INDUCED SEDATION IN RATS [J].
COWEN, PJ ;
GREEN, AR ;
NUTT, DJ ;
MARTIN, IL .
NATURE, 1981, 290 (5801) :54-55
[5]   2-HYDRAZINOTHIOPHENE-3-CARBONIC ACID-ESTERS [J].
HENTSCHEL, M ;
GEWALD, K .
JOURNAL FUR PRAKTISCHE CHEMIE-PRACTICAL APPLICATIONS AND APPLIED CHEMISTRY, 1974, 316 (05) :878-880
[6]  
HUDDLESTON PR, 1980, J CHEM RES-S, P238
[7]   SELECTIVE ANTAGONISTS OF BENZODIAZEPINES [J].
HUNKELER, W ;
MOHLER, H ;
PIERI, L ;
POLC, P ;
BONETTI, EP ;
CUMIN, R ;
SCHAFFNER, R ;
HAEFELY, W .
NATURE, 1981, 290 (5806) :514-516
[8]  
KASLOW EE, 1953, J ORG CHEM, V18, P55
[9]   THE PROCONVULSANT AND DIAZEPAM-REVERSING EFFECTS OF ETHYL-BETA-CARBOLINE-3-CARBOXYLATE [J].
OAKLEY, NR ;
JONES, BJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 68 (03) :381-382
[10]   DOES THE REVERSAL OF THE ANTI-CONFLICT EFFECT OF PHENOBARBITAL BY BETA-CCE AND FG-7142 INDICATE BENZODIAZEPINE RECEPTOR-MEDIATED ANXIOGENIC PROPERTIES [J].
PETERSEN, EN ;
PASCHELKE, G ;
KEHR, W ;
NIELSEN, M ;
BRAESTRUP, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 82 (3-4) :217-221