IN VITRO RELEASE AND IN VIVO PENETRATION STUDIES OF A TOPICAL STEROID FROM NONAQUEOUS VEHICLES

被引：38

作者：

DEMPSKI, RE

PORTNOFF, JB

WASE, AW

机构：

[1] Pharmaceutical Research and Development Department, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania

[2] Merck Institute, Rahway, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 05期

关键词：

Dexamethasone‐[!sup]14[!/sup]C release; penetration—ointments; Penetration; in vivo; correlation—in vitro release rates; Topical vehicles—drug release; penetration; Vehicle solubilizing effect—dexamethasone release;

D O I：

10.1002/jps.2600580513

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method is described for studying the in vitro release of dexamethasone and some of its esters from gelled isopropyl myristate, petrolatum USP, and two other nonaqueous vehicles. The effect of steroid solubility in the major component of each vehicle is discussed. In vivo penetration of dexamethasone‐14C through stripped human skin showed good correlation with in vitro studies. No difference in the vehicles was observed with intact skin. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：579 / &

共 14 条

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