CHRONIC TREATMENT WITH MK-801 INCREASES THE QUINOLINIC ACID-INDUCED LOSS OF D-1 DOPAMINE-RECEPTORS IN RAT STRIATUM

被引：17

作者：

NORMAN, AB

FORD, LM

KOLMONPUNPORN, M

SANBERG, PR

机构：

[1] UNIV CINCINNATI,COLL MED,DEPT ANAT,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,COLL MED,DEPT PHYSIOL,CINCINNATI,OH 45267

[3] UNIV CINCINNATI,COLL MED,DEPT PSYCHOL & NEUROSURG,CINCINNATI,OH 45267

[4] CHILDRENS HOSP MED CTR,DEPT PEDIAT NEUROL,CINCINNATI,OH 45267

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 03期

关键词：

(Supersensitivity); Dopamine D-1 receptors; Excitotoxins; MK-801; NMDA receptors; Quinolinic acid;

D O I：

10.1016/0014-2999(90)90031-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following withdrawal from short-term treatment with the non-competitive N-methyl-d-aspartate receptor antagonist MK-801 (1 mg/kg per day) there was no significant change in the Bmax or KD of [3H]SCH23390 binding to dopamine D-1 receptors in rat striatum. Intrastriatal injection of the excitotoxin quinolinic acid (100 nmol) produced a significant decrease in [3H]SCH23390 binding. In rats withdrawn from chronic MK-801 treatment quinolinic acid produced a significantly greater loss of [3H]SCH23390 binding sites than in rats not treated with MK-801. These data indicated that striatal neurons are hypersensitive to the neurotoxic actions of quinolinic acid following withdrawal from chronic MK-801 treatment. © 1990.

引用

页码：363 / 366

页数：4

共 10 条

[1] D-1 DOPAMINE RECEPTOR CHANGES AFTER STRIATAL QUINOLINIC ACID LESION [J].