HUNTINGTONS-DISEASE - ABNORMALITY OF LYMPHOCYTE CAPPING

被引：21

作者：

NORONHA, ABC ^{[1
]}

ROOS, RP ^{[1
]}

ANTEL, JP ^{[1
]}

ARNASON, BGW ^{[1
]}

机构：

[1] UNIV CHICAGO,PRITZKER SCH MED,CHICAGO,IL 60637

来源：

ANNALS OF NEUROLOGY | 1979年 / 6卷 / 05期

关键词：

D O I：

10.1002/ana.410060512

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Concanavalin A‐induced lymphocyte capping was studied in 30 patients with Huntington's disease (HD) and 39 controls. A significant decrease in lymphocyte capping was seen in the 24 patients with HD less than 60 years of age compared to 25 age‐matched controls (p < 0.01); above age 60, differences between patients with HD and controls were not significant. These findings lend support to previous observations that generalized membrane abnormalities are present in patients with HD. Studies of HD lymphocyte capping may permit a detailed analysis of membrane function in cells that are readily obtained from living patients. Copyright © 1979 American Neurological Association

引用

页码：447 / 450

页数：4

共 21 条

[1]

ALBERTINI DF, 1977, J CELL SCI, V26, P57

[2] MITOGEN RESPONSIVENESS AND SUPPRESSOR CELL-FUNCTION IN MULTIPLE-SCLEROSIS - INFLUENCE OF AGE AND DISEASE ACTIVITY [J].