HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION IN CD4+ LYMPHOCYTES-T GENETICALLY DEFICIENT IN LFA-1 - LFA-1 IS REQUIRED FOR HIV-MEDIATED CELL-FUSION BUT NOT FOR VIRAL TRANSMISSION

被引：120

作者：

PANTALEO, G ^{[1
]}

BUTINI, L ^{[1
]}

GRAZIOSI, C ^{[1
]}

POLI, G ^{[1
]}

SCHNITTMAN, SM ^{[1
]}

GREENHOUSE, JJ ^{[1
]}

GALLIN, JI ^{[1
]}

FAUCI, AS ^{[1
]}

机构：

[1] NIAID,CLIN INVEST LAB,BETHESDA,MD 20892

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 173卷 / 02期

关键词：

D O I：

10.1084/jem.173.2.511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study, we demonstrated that expression of the LFA-1 molecule is necessary for cell fusion and syncytia formation in human immunodeficiency virus (HIV)-infected CD4+ T lymphocytes. In contrast, the lack of expression of LFA-1 does not influence significantly cell-to-cell transmission of HIV. In fact, LFA-1- T lymphocytes obtained from a leukocyte adhesion deficiency patient were unable to fuse and form syncytia when infected with HIV-1 or HIV-2, despite the fact that efficiency of HIV infection (i.e., virus entry, HIV spreading, and levels of virus replication) was comparable with that observed in LFA-1+ T lymphocytes. In addition, we provide evidence that LFA-1 by mediating cell fusion contributes to the depletion of HIV-infected CD4+ T lymphocytes in vitro.

引用

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页码：511 / 514

页数：4

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