AMINOGLYCOSIDES MODIFY THE INVITRO METACHROMATIC REACTION AND MURINE GENERALIZED SHWARTZMAN PHENOMENON INDUCED BY SALMONELLA-MINNESOTA R595 LIPOPOLYSACCHARIDE

被引：19

作者：

FOCA, A ^{[1
]}

MATERA, G ^{[1
]}

IANNELLO, D ^{[1
]}

BERLINGHIERI, MC ^{[1
]}

LIBERTO, MC ^{[1
]}

机构：

[1] UNIV MESSINA,IST MICROBIOL,I-98100 MESSINA,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 10期

关键词：

D O I：

10.1128/AAC.35.10.2161

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Endotoxin-neutralizing actvity may be an important property for antibiotics to be used in severe sepsis. Several antibiotics, belonging to different classes, were evaluated as to their endotoxin-neutralizing ability, using the inhibition of an in vitro metachromatic assay for lipopolysaccharides and a murine generalized Shwartzman reaction model. Gentamicin, amikacin, and sisomicin have been found to share significant in vitro antiendotoxin activity at an antibiotic/endotoxin ratio as low as 1.0/5 (by weight) and to reduce the murine generalized Shwartzman reaction at an antibiotic/endotoxin ratio of 3.3/5.

引用

页码：2161 / 2164

页数：4

共 22 条

[1] INHIBITION OF ENDOTOXIN REACTIVITY BY AMINOGLYCOSIDES [J].