THE FREQUENCY OF P53 IMMUNOSTAINING IN ASBESTOS-ASSOCIATED MESOTHELIOMAS AND NON-ASBESTOS-ASSOCIATED MESOTHELIOMAS

被引：14

作者：

MAYALL, FG ^{[1
]}

GODDARD, H ^{[1
]}

GIBBS, AR ^{[1
]}

机构：

[1] UNIV WALES COLL MED,CARDIFF CF4 4XN,S GLAM,WALES

来源：

HISTOPATHOLOGY | 1993年 / 22卷 / 04期

关键词：

MESOTHELIOMA; ASBESTOS; P53; PROTEIN; IMMUNOHISTOCHEMISTRY; CARCINOGENESIS;

D O I：

10.1111/j.1365-2559.1993.tb00140.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been suggested that asbestos might have an important role in the development of p53 mutations in mesotheliomas. The objective of this study was to examine asbestos-associated mesotheliomas and non-asbestos-associated mesotheliomas to establish whether the frequency of p53 immunostaining and, by implication, p53 gene mutation is related to asbestos exposure. Immunopositivity for p53 was found in seven (44%) of the 16 mesotheliomas examined. The frequency was approximately the same in both the asbestos-associated mesotheliomas and the non-asbestos-associated mesotheliomas. It is concluded that the frequency of p 5 3 immunostaining in mesotheliomas and, by implication, the frequency of p53 gene mutation is probably not related to asbestos exposure.

引用

页码：383 / 386

页数：4

共 32 条

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