APLASIA AFTER DONOR LYMPHOCYTE INFUSION (DLI) FOR CML IN RELAPSE AFTER SEX-MISMATCHED BMT - RECOVERY OF DONOR-TYPE HEMATOPOIESIS PREDICTED BY NONISOTOPIC IN-SITU HYBRIDIZATION (ISH)

被引：9

作者：

GARICOCHEA, B ^{[1
]}

VANRHEE, F ^{[1
]}

SPENCER, A ^{[1
]}

CHASE, A ^{[1
]}

LIN, F ^{[1
]}

CROSS, NCP ^{[1
]}

GOLDMAN, JM ^{[1
]}

机构：

[1] LRF,CTR ADULT LEUKAEMIA,LONDON,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 88卷 / 02期

关键词：

BMT; IN SITU HYBRIDIZATION; CML; BCR/ABL MINIMAL RESIDUAL DISEASE;

D O I：

10.1111/j.1365-2141.1994.tb05039.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a patient with CML in relapse after a sex-mismatch bone marrow transplant who was treated with donor lymphocyte infusions and developed severe marrow aplasia 3 months later. As cytogenetic analysis at this point was not possible because of the very low number of marrow cells available, we used in situ hybridization (ISH) for sex chromosomes and the BCR/ABL gene together with quantitative PCR to monitor the patient's response. The results suggest that recovering haemopoiesis was derived from donor cells and contributed to the decision not to transfuse donor marrow cells on a second occasion.

引用

页码：400 / 402

页数：3

共 8 条

[1] ANTIN JH, 1993, BLOOD, V82, P2273
[2] CROSS NCP, 1993, BLOOD, V82, P1929
[3] DURNAM DM, 1989, BLOOD, V74, P2220
[4] GARICOCHEA B, 1994, LEUKEMIA, V8, P1197
[5] INDUCTION OF GRAFT-VERSUS-HOST DISEASE AS IMMUNOTHERAPY FOR RELAPSED CHRONIC MYELOID-LEUKEMIA
PORTER, DL
ROTH, MS
MCGARIGLE, C
FERRARA, JLM
ANTIN, JH
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (02) : 100 - 106
[6] TAKAHASHI E, 1990, HUM GENET, V86, P14
[7] DETECTION OF BCR-ABL FUSION IN CHRONIC MYELOGENEOUS LEUKEMIA BY INSITU HYBRIDIZATION
TKACHUK, DC
WESTBROOK, CA
ANDREEFF, M
DONLON, TA
CLEARY, ML
SURYANARAYAN, K
HOMGE, M
REDNER, A
GRAY, J
PINKEL, D
[J]. SCIENCE, 1990, 250 (4980) : 559 - 562
[8] VANRHEE F, 1994, BLOOD, V83, P3377

← 1 →