DOUBLE-BLIND DEVELOPMENTAL EVALUATION AT 1-YEAR CORRECTED AGE OF 597 PREMATURE-INFANTS WITH BIRTH WEIGHTS FROM 500 TO 1350 GRAMS ENROLLED IN 3 PLACEBO-CONTROLLED TRIALS OF PROPHYLACTIC SYNTHETIC SURFACTANT

Infants enrolled in three clinical trials of prophylactic treatment for respiratory distress syndrome with a single dose of synthetic surfactant (Exosurf Neonatal) or air placebo were monitored through 1-year adjusted age, A total of 1046 infants with birth weights from 500 to 4350 gm were enrolled in the three trials; of the 735 infants who survived to 1 year of age, follow-up evaluations were completed for 597 (80%, air placebo group; 82%, synthetic surfactant group), Infants in the air placebo and synthetic surfactant treatment groups had no differences in general health, growth, or neurodevelopmental outcomes or impairments, These follow-up results at 1-year adjusted age for infants who received a single dose of synthetic surfactant indicate that a single dose of synthetic surfactant reduces mortality without increasing the absolute number or proportion of infants with impairments at 1 year of age.