METABOLIC FATES OF GRAMINE IN BARLEY .I. MECHANISM OF INCORPORATION OF GRAMINE INTO TRYPTOPHAN IN BARLEY SHOOTS

被引：9

作者：

DIGENIS, GA

机构：

[1] Departments of Materia Medica and Pharmaceutical Chemistry, College of Pharmacy, University of Kentucky, Lexington, Kentucky

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Biotransformation—radiolabeled gramine; Column chromatography—separation; Gramine in barley—metabolism; Liquid scintillation counting—radioactivity determination; Radioautography—analysis; TLC—separation; identity; Tryptophan—gramine metabolite; UV spectrophotometry—identity;

D O I：

10.1002/jps.2600580104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gramine tagged on the methylene group of its side chain with 14C and tritium was administered to 60‐day‐old barley shoots and the alkaloid allowed to be metabolized for 7 days. It was found that 0.84% of the radioactivity was incorporated into plant tryptophan, and the ratio of 14C to tritium remained the same as that of the administered gramine. A mechanistic rationalization is proposed for the biotransformation. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：39 / &

共 34 条

[1] THE BIOGENESIS OF ALKALOIDS .4. THE FORMATION OF GRAMINE FROM TRYPTOPHAN IN BARLEY
BOWDEN, K
MARION, L
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1951, 29 (12): : 1037 - 1042
[2] THE BIOGENESIS OF ALKALOIDS .5. RADIOAUTOGRAPHS OF BARLEY LEAVES FED WITH TRYPTOPHAN-BETA-C-14
BOWDEN, K
MARION, L
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1951, 29 (12): : 1043 - &
[3] BOYER PD, 1960, ENZYMES A ED, V2, P122
[4] BOYER PD, 1960, ENZYMES A ED, V2, P162
[5] BRANDT K, 1935, J PHYSIOL CHEM, V235, P37
[6] BRAUNSTEIN AE, 1960, ENZYMES A, V2, P162
[7] BRAUNSTEIN AE, 1960, ENZYMES A, V2, P122
[8] DALY JW, 1963, ANGEW CHEM INT ED, V2, P425
[9] BIOTRANSFORMATION OF GRAMINE INTO TRYPTOPHAN IN BARLEY SHOOTS
DIGENIS, GA
FARAJ, BA
ABOUCHAA.CI
[J]. BIOCHEMICAL JOURNAL, 1966, 101 (02) : C27 - &
[10] DIGENIS GA, 1966, LEBANESE PHARM J, V9, P47

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