ROLE OF HOMOCYTOTROPIC ANTIBODIES IN PATHOGENESIS OF GASTRIC-ULCER

被引：11

作者：

ANDRE, F

ANDRE, C

VIALARD, JL

机构：

[1] Unité de recherche de physiopathologie digestive, Inserm U-45, Hôpital Edouard-Herriot, Lyon

来源：

DIGESTION | 1979年 / 19卷 / 03期

关键词：

Anaphylaxis; Disodium cromoglycate; Gastric ulcer; Immunoglobulins; Mast cells;

D O I：

10.1159/000198341

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Praomys (Mastomys) natalensis were sensitised by peritoneal injection of ovalbumin mixed with aluminium hydroxide. The animals developed homocytotropic IgE and IgG 1 antibodies. When presensitised animals were challenged with ovalbumin in the gastric wall, a gastric ulcer appeared. This ulceration, induced by an immunological release of histamine, could be inhibited by the administration of disodium cromoglycate. The present model is useful for producing a gastric ulcer in a determined site. It supports the theory of a possible allergic component in the pathogenesis of the human disease. © 1979 S. Karger AG, Basel.

引用

页码：175 / 179

页数：5

共 14 条

[1]

ANDRE C, 1976, LANCET, V1, P964

[2] GLUTARALDEHYDE CYANURIC CHLORIDE AND TETRAAZOTIZED O-DIANISISDINE AS COUPLING REAGENTS IN PASSIVE HEMAGGLUTINATION TEST [J].