EXPRESSION OF PROTEIN DISULFIDE ISOMERASE IN CULTURED RAT-LIVER EPITHELIAL-CELLS IS UNRELATED TO THE GROWTH INHIBITORY EFFECT OF TGF-BETA-1

被引：1

作者：

TSAO, MS

GRISHAM, JW

机构：

[1] MCGILL UNIV,MONTREAL H3G 1A4,QUEBEC,CANADA

[2] UNIV N CAROLINA,SCH MED,DEPT PATHOL,CHAPEL HILL,NC 27599

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91441-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of TGF-β1 treatment on the level of protein disulfide isomerase(PDI) mRNA in normal and chemically or spontaneously transformed rat liver epithelial cell lines was investigated. TGF-β1 at 1 or 10 ng/ml concentrations did not significantly decrease the mRNA level of PDI at 4 or 24 hours after exposure to TGF-β1, irrespective whether the cell line was sensitive or resistant to the growth-inhibitory effect of TGF-β1 at these concentrations. The results indicate that in normal or neoplastic rat liver epithelial cells, the expression of PDI is unrelated to the growth inhibitory effect of TGF-β1. © 1991.

引用

页码：478 / 482

页数：5

共 14 条

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