INHIBITION OF TUMOR-PROMOTER-ENHANCED H-3 CHOLINE INCORPORATION INTO CELLULAR PHOSPHOLIPIDS BY PHLOROGLUCINOL DERIVATIVES FROM MALLOTUS-JAPONICUS

被引：12

作者：

ARISAWA, M

FUJITA, A

MORITA, N

OKUYAMA, T

NISHINO, H

机构：

[1] MEIJI COLL PHARM, DEPT PHARMACOGNOSY & PHYTOCHEM, SETAGAYA KU, TOKYO 154, JAPAN

[2] KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIGYOJ KU, KYOTO 602, JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 05期

关键词：

D O I：

10.1021/np50077a029

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin [1], markedly inhibited the incorporation of H-3-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.

引用

页码：1409 / 1412

页数：4

共 24 条

[1]

ARISAWA M, 1990, CHEM PHARM BULL, V38, P1624, DOI 10.1248/cpb.38.1624

[2] STUDIES ON CYTOTOXIC CONSTITUENTS IN PERICARPS OF MALLOTUS-JAPONICUS .5. 3 NEW PHLOROGLUCINOL DERIVATIVES, BUTYRYLMALLOTOCHROMANOL, ISOBUTYRYLMALLOTOCHROMANOL, AND MALLOTOJAPONOL [J].