INCREASED URINARY TRANSFERRIN EXCRETION IN EXERCISING NORMOALBUMINURIC INSULIN-DEPENDENT DIABETIC-PATIENTS

被引：3

作者：

ODONNELL, MJ

MARTIN, P

CAVAN, D

PARKES, A

CHAPMAN, J

CHAPMAN, C

BARNETT, AH

机构：

[1] E BIRMINGHAM DIST GEN HOSP,CTR UNDERGRAD,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[2] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[3] GEN INFIRM,DEPT CHEM PATHOL & IMMUNOL,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[4] E BIRMINGHAM DIST GEN HOSP,RESP PHYSIOL LAB,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1991年 / 28卷

关键词：

DIABETIC NEPHROPATHY; EXERCISE; PROTEINURIA; ALBUMIN;

D O I：

10.1177/000456329102800506

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The median rate of urinary transferrin excretion is greatly increased by exercise in subjects with uncomplicated type 1 (insulin-dependent) diabetes. This increase is proportionally far greater than that seen in urinary albumin excretion rate after the same exercise. Non-diabetic control subjects showed no rise in urinary transferrin excretion rate following exercise. N-acetyl-beta-D-glucosaminidase excretion rate was higher in diabetic than control groups but did not rise with exercise. Our results suggest that patients with apparently uncomplicated diabetes have abnormal renal function. In this group an elevated urinary transferrin excretion rate appears to be a more sensitive indicator of altered renal function than is elevated albumin excretion rate. The mechanism underlying exercise-induced urinary loss of transferrin remains to be elucidated.

引用

页码：456 / 460

页数：5

共 19 条

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