EFFECTS OF EXTENDED LOW-DOSE-RATE EXPOSURE TO CS-137 DETECTED BY FLOW-CYTOMETRIC ENUMERATION OF MICRONUCLEATED ERYTHROCYTES IN MOUSE PERIPHERAL-BLOOD

被引：28

作者：

GRAWE, J ^{[1
]}

ZETTERBERG, G ^{[1
]}

AMNEUS, H ^{[1
]}

机构：

[1] UPPSALA UNIV,DEPT GENET,S-75007 UPPSALA,SWEDEN

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1993年 / 63卷 / 03期

关键词：

D O I：

10.1080/09553009314550451

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An automated variant the of micronucleus assay for erythrocytes in mouse peripheral blood has recently been developed. The flow-cytometric technique used allows very large numbers of erythrocytes to be analysed with a relatively small effort. Here we report the potential of this method to detect a response to extended low-dose-rate exposure to gamma-irradiation. The mice were irradiated with a Cs-137 source at a dose rate of 4-8 cGy/day for 26 days. Sampling was continued for another 39 days after irradiation. Elevated frequencies compared with the control group were found at days 2, 9 and 20 after the start of the irradiation for micronucleated polychromatic erythrocytes, and at days 9, 20, 29, 42, 51 and 65 for micronucleated normochromatic erythrocytes.

引用

页码：339 / 347

页数：9

共 26 条

[1] SHORT-TERM TESTS FOR TRANSPLACENTALLY ACTIVE CARCINOGENS .1. MICRONUCLEUS FORMATION IN FETAL AND MATERNAL MOUSE ERYTHROBLASTS [J].