THE COMPLETE SEQUENCE OF A HUMAN ASTROVIRUS

被引：95

作者：

WILLCOCKS, MM

BROWN, TDK

MADELEY, CR

CARTER, MJ

机构：

[1] UNIV NEWCASTLE UPON TYNE, SCH PATHOL SCI, DIV VIROL, NEWCASTLE UPON TYNE NE2 4HH, ENGLAND

[2] UNIV CAMBRIDGE, NEW ADDENBROOKES HOSP, DEPT PATHOL, DIV VIROL, CAMBRIDGE CB2 2QQ, ENGLAND

[3] ROYAL VICTORIA INFIRM, DEPT VIROL, NEWCASTLE UPON TYNE NE1 4LP, TYNE & WEAR, ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

关键词：

D O I：

10.1099/0022-1317-75-7-1785

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3' ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.

引用

页码：1785 / 1788

页数：4

共 24 条

[1] THE COMPLETE NUCLEOTIDE-SEQUENCE OF A FELINE CALICIVIRUS [J].