EPIDERMAL GROWTH-FACTOR INDUCES SERINE PHOSPHORYLATION OF ACTIN

被引：27

作者：

VANDELFT, S

VERKLEIJ, AJ

BOONSTRA, J

HENEGOUWEN, PMPVE

机构：

[1] Department of Molecular Cell Biology, Utrecht University, 3584 CH Utrecht

来源：

FEBS LETTERS | 1995年 / 357卷 / 03期

关键词：

EGF; EGF-RECEPTOR; ACTIN; PHOSPHORYLATION;

D O I：

10.1016/0014-5793(94)01359-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulation of cells by epidermal growth factor induces a rapid polymerisation of actin in the cortical skeleton. Activation of the EGF-receptor leads to autophosphorylation and to phosphorylation of specific intracellular substrates. Here we show that actin is phosphorylated in vitro and in vivo upon EGF stimulation. Two-dimensional phospho-amino acid analysis shows that phosphorylation occurs on serine, not on tyrosine residues.

引用

页码：251 / 254

页数：4

共 26 条

[1]

AKIYAMA T, 1986, J BIOL CHEM, V261, P4797

[2] RAPID PHOSPHORYLATION AND REORGANIZATION OF EZRIN AND SPECTRIN ACCOMPANY MORPHOLOGICAL-CHANGES INDUCED IN A-431 CELLS BY EPIDERMAL GROWTH-FACTOR [J].