EFFECTS OF AGARWOOD EXTRACTS ON THE CENTRAL-NERVOUS-SYSTEM IN MICE

被引：61

作者：

OKUGAWA, H ^{[1
]}

UEDA, R ^{[1
]}

MATSUMOTO, K ^{[1
]}

KAWANISHI, K ^{[1
]}

KATO, A ^{[1
]}

机构：

[1] KOBE WOMENS COLL PHARM,HIGASHINADA KU,KOBE 658,JAPAN

来源：

PLANTA MEDICA | 1993年 / 59卷 / 01期

关键词：

AGARWOOD; AQUILARIA-SP; AQUILARIA-MALACCENSIS BENTH; THYMELAEACEAE; SPONTANEOUS MOTILITY; HEXOBARBITURATE-INDUCED SLEEPING TIME; HYPOTHERMIA; ANALGESIA;

D O I：

10.1055/s-2006-959599

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Agarwood (Jinkoh in Japanese) is an Oriental medicine for use as a sedative. Neuropharmacological studies have been conducted with the extracts of petroleum ether, benzene, chloroform, and water from agarwood (Aquilaria sp.; probably Aquilaria malaccensis Benth.) in mice. The benzene extract showed a reducing effect in spontaneous motility, a prolonging effect on hexobarbiturate-induced sleeping time, a hypothermic effect in terms of rectal temperature, and a suppressive effect on acetic acid-writhing by oral administration. Fr. 1 of the three fractions which were obtained from the benzene extract by column chromatography was found to produce more positive effects on these neuropharmacological tests than the original benzene extract. These facts suggest that the benzene extractable compounds of agarwood possess potent central nervous system depressant activities.

引用

页码：32 / 36

页数：5

共 7 条

[1] JINKOHOL, A PREZIZANE SESQUITERPENE ALCOHOL FROM AGARWOOD [J].