APPROACHES TO PREPARATION OF 3'-DEOXYNUCLEOSIDES

被引:13
作者
JOHNSTON, GA
机构
[1] Department of Physiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT
关键词
D O I
10.1071/CH9680513
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The stability of 3′-O-sulphonyl derivatives of uridine towards nucleophilic displacement indicates that sulphonate replacement is unlikely to offer a general route to 3′-deoxynucleosides. The preparation of 3′-deoxyuridine by direct iodination of 2′, 5′-di-O-trityluridine with triphenylphosphite methiodide followed by catalytic hydrogenolysis is discussed as such a general route dependent on the availability of suitably protected nucleoside starting materials. Acyl migration takes place under the conditions of the iodination reaction, limiting the choice of protecting groups. © 1968 CSIRO. All rights reserved.
引用
收藏
页码:513 / &
相关论文
共 34 条