HETEROCYCLIC SUBSTITUTED UREAS .I. IMMUNOSUPPRESSION AND VIRUS INHIBITION BY BENZIMIDAZOLEUREAS

In an effort to define the structure-activity relationships (SAR) for immunosuppression and antiviral activity, a series of 1-(benziniidazol-2-yl)-3-substituted ureas and their close analogs have been synthesized. Many of these compounds display potent immunosuppression in the sheep erythrocyte test, in mice, the most effective being approximately 2000 times as active an azathioprine. In addition, these compounds have potent, in vivo antiviral activity in several viral diseases. We have defined the antiviral SAR using mice infected with Coxsackie A21 virus (Coe). © 1969, American Chemical Society. All rights reserved.