HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CHLORDIAZEPOXIDE AND ITS MAJOR METABOLITES IN BIOLOGICAL-FLUIDS

被引：20

作者：

PEAT, MA ^{[1
]}

FINKLE, BS ^{[1
]}

DEYMAN, ME ^{[1
]}

机构：

[1] UNIV UTAH,MED CTR,DEPT PATHOL,SALT LAKE CITY,UT 84112

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 11期

关键词：

Chlordiazepoxide—analysis; high‐pressure liquid chromatography; biological fluids; metabolites; High‐pressure liquid chromatography—analysis; chlordiazepoxide and metabolites; Sedatives—chlordiazepoxide; high‐pressure liquid chromatographic analysis;

D O I：

10.1002/jps.2600681139

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple, isocratic, reversed‐phase, high‐pressure liquid chromatographic procedure was developed for the determination of chlordiazepoxide and its major metabolites in plasma and urine. The within‐run coefficient of variation was 3.4‐8.0%, and the day‐to‐day variation was 4.0‐8.0%. Recoveries of 80‐91% with sensitivity limits of 50 ng/ml were obtained for the parent drug and its metabolites. Plasma and urine samples collected after single intravenous and single oral doses were analyzed using this procedure. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1467 / 1468

页数：2

共 20 条

[1] PHARMACOKINETIC AND BIO-PHARMACEUTIC PROFILE OF CHLORDIAZEPOXIDE HCL IN HEALTHY SUBJECTS - SINGLE-DOSE STUDIES BY INTRAVENOUS, INTRAMUSCULAR, AND ORAL ROUTES [J].