NEURONAL DEGENERATION INDUCED BY STEREOTAXIC INJECTION OF BETA-BUNGAROTOXIN INTO RAT-BRAIN

被引：26

作者：

HANLEY, MR

EMSON, PC

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC BIOL,BERKELEY,CA 94720

[2] MED SCH CAMBRIDGE,DEPT PHARMACOL,MRC,NEUROCHEM PHARMACOL UNIT,CAMBRIDGE CB2 2QD,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 02期

关键词：

D O I：

10.1016/0304-3940(79)90117-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The presynaptic protein neurotoxin β-bungarotoxin (β-bgt) caused degeneration of neurons, following stereotaxic administration into rat brain. Focal lesions were induced with as little as 0.1 ng (5 fmol) of β-bgt; indicating that the toxin is over 106 times more potent than kainic acid. More extensive studies in the septo-hippocampal system showed β-bgt lesions affected both cell bodies and nerve terminals and were not neurotransmitter-specific. The endogenous phospholipase A2 activity of β-bgt did not simply account for the creation of lesions since an acidic phospholipase A isoenzyme from Vipera russellii was virtually inactive in causing neuronal damage. © 1979.

引用

页码：143 / 148

页数：6

共 18 条

[1] ACUTE MUSCLE DENERVATION INDUCED BY BETA-BUNGAROTOXIN [J].