PERITONEAL MACROPHAGE RESPONSE - AN INVIVO MODEL FOR THE STUDY OF SYNTHETIC MATERIALS

被引：35

作者：

FREYRIA, AM

CHIGNIER, E

GUIDOLLET, J

LOUISOT, P

机构：

[1] FAC MED ALEXIS CARREL,INSERM,U331,8 RUE G PARADIN,F-69372 LYONS 08,FRANCE

[2] INSERM,U37,F-69500 BRON,FRANCE

[3] INSERM,U189,F-69921 DULLINS,FRANCE

来源：

BIOMATERIALS | 1991年 / 12卷 / 02期

关键词：

CELL-MATERIAL INTERACTIONS; PERITONEUM; MACROPHAGES;

D O I：

10.1016/0142-9612(91)90187-F

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study was designed to validate an in vivo model in rat to study cell-implant interactions. Pieces of Dacron(R) and Goretex(R) and polydimethylsiloxane (reference material) precoated or not were implanted in the peritoneal cavity. In some cases the peritoneal cells were stimulated before the implantation. Macrophage phagocytosis and fibrinocoagulolytic activities were investigated in parallel with morphological studies 6 h after implantation. A graded cell response related to the different situations was observed, providing a measure of the material's behaviour. Using this model, other investigations of macrophage/polymer can be conducted, especially to explain implant encapsulation.

引用

页码：111 / 118

页数：8

共 21 条

[1] THE CELL BIOLOGY OF MACROPHAGE ACTIVATION [J].