COMPARATIVE KINETICS OF SERUM AND VITREOUS-HUMOR DIGOXIN CONCENTRATIONS IN A GUINEA-PIG MODEL .1. INTRAVENOUS ADMINISTRATION OF DIGOXIN

被引：4

作者：

DONNELLY, B

BALKON, J

BIDANSET, JH

BELMONTE, A

BARLETTA, M

MANNING, T

机构：

[1] ST JOHNS UNIV,COLL PHARM & ALLIED HLTH PROFESS,DEPT PHARMACEUT SCI,JAMAICA,NY 11439

[2] NASSAU CTY MED EXAMINERS OFF,TOXICOL LAB,E MEADOW,NY

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1991年 / 15卷 / 02期

关键词：

D O I：

10.1093/jat/15.2.60

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The pharmacokinetics of a single intravenous dose of digoxin in the guinea pig was investigated with emphasis on the penetration of digoxin into the vitreous humor. A controlled study was undertaken and data was collected which indicated that digoxin follows an open, two-compartment pharmacokinetic model with a terminal half-life of 318 minutes. The data indicated that the ratio of vitreous concentrations to serum concentrations were determined to be equal following an initial tissue distribution phase.

引用

页码：60 / 62

页数：3

共 16 条

[1] HUMAN VITREOUS LEVELS OF CEFAMANDOLE AND MOXALACTAM [J].

AXELROD, JL ;

KLEIN, RM ;

BERGEN, RL ;

SHEIKH, MZ .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1986, 101 (06) :684-687

[2]

AXELROD JL, 1985, OPHTHALMOLOGY, V94, P30

[3]

BARZA M, 1982, INVEST OPHTH VIS SCI, V22, P720

[4]

BARZA M, 1981, INVEST OPHTH VIS SCI, V20, P509

[5]

CHEN NBW, 1985, J FORENSIC SCI, V30, P213

[6]

FELBY S, 1975, FORENS SCI, V6, P31

[7]

GARRIOTT JC, 1989, AM ACADEMY FORENSIC

[8]

LOGAN BK, 1989, FEB AM AC FOR SCI AN

[9]

MITTLEMAN RE, 1982, J FORENSIC SCI, V27, P955

[10]

OJANPERA I, 1986, J FORENSIC SCI, V31, P707

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