SEQUENCE-DEPENDENT FORMATION OF ALKYL DNA ADDUCTS - A REVIEW OF METHODS, RESULTS, AND BIOLOGICAL CORRELATES

被引：42

作者：

RICHARDSON, FC

RICHARDSON, KK

机构：

[1] Toxicology Division, Lilly Research Laboratories, Eli Lilly and Co., Greenfield

来源：

MUTATION RESEARCH | 1990年 / 233卷 / 1-2期

关键词：

Alkyl DNA adducts; Alkylating agents; DNA; DNA adducts; sequence adduct formation;

D O I：

10.1016/0027-5107(90)90157-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Understanding the influence of the DNA sequence on chemical-DNA interactions may provide insight into the processes of chemical carcinogenesis and mutagenesis. This article provides a brief overview of studies and methods devoted to examining the distribution of DNA adducts produced by alkylating agents. Particular emphasis is placed on discussion of DNA adducts generated by simple alkylating agents and the role that their distribution may play in the generation of mutational hotspots. © 1990.

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页码：127 / 138

页数：12

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