EFFICACY AND SAFETY OF VAGUS NERVE-STIMULATION IN PATIENTS WITH COMPLEX PARTIAL SEIZURES

被引：106

作者：

UTHMAN, BM ^{[1
]}

WILDER, BJ ^{[1
]}

HAMMOND, EJ ^{[1
]}

REID, SA ^{[1
]}

机构：

[1] DEPT VET AFFAIRS MED CTR, NEUROL SURG SECT, GAINESVILLE, FL USA

来源：

EPILEPSIA | 1990年 / 31卷

关键词：

Electrical stimulation; Epilepsy; Prognosis; Safety; Seizures; Vagus nerve;

D O I：

10.1111/j.1528-1157.1990.tb05849.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Summary: A clinical trial of chronic intermittent vagal stimulation in five patients suggests that the procedure may be safe and effective as adjunctive treatment of medically intractable seizures of partial onset. Patients tolerated well the implantation of the neurocybernetic prosthesis and the vagal stimulation without serious physiological or lifestyle changes. Stimulation of the vagus nerve either reduced the seizure frequency or decreased the duration or intensity of seizures. Adverse side effects were limited to a tingling sensation in the throat and hoarseness during stimulation. A major complication was mechanical interruption of the wire‐electrode circuitry, with consequent cessation of stimulation. The small number of patients and the relatively short follow‐up period make this a pilot study, but the results are promising. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：S44 / S50

页数：7

共 14 条

[1] CONSIDERATIONS FOR SAFETY WITH CHRONICALLY IMPLANTED NERVE ELECTRODES
AGNEW, WF
MCCREERY, DB
[J]. EPILEPSIA, 1990, 31 : S27 - S32
[2] [Anonymous], 1981, Epilepsia, V22, P489
[3] CAR A, 1975, EXP BRAIN RES, V22, P197
[4] CHASE MICHAEL H., 1967, BRAIN RES, V5, P236, DOI 10.1016/0006-8993(67)90089-3
[5] VAGUS NERVE-STIMULATION IN HUMANS - NEUROPHYSIOLOGICAL STUDIES AND ELECTROPHYSIOLOGICAL MONITORING
HAMMOND, EJ
UTHMAN, BM
REID, SA
WILDER, BJ
RAMSAY, RE
[J]. EPILEPSIA, 1990, 31 : S51 - S59
[6] VAGAL REPRESENTATION IN CEREBELLUM OF CAT
HENNEMANN, HE
RUBIA, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1978, 375 (02): : 119 - 123
[7] Magnes J., 1961, ARCH ITAL BIOL, V99, P33
[8] EVOKED CORTICAL RESPONSES TO VAGAL, LARYNGEAL AND FACIAL AFFERENTS IN MONKEYS UNDER CHLORALOSE ANAESTHESIS
OBRIEN, JH
PIMPANEAU, A
ALBEFESS.D
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1971, 31 (01): : 7 - +
[9] SURGICAL TECHNIQUE FOR IMPLANTATION OF THE NEUROCYBERNETIC PROSTHESIS
REID, SA
[J]. EPILEPSIA, 1990, 31 : S38 - S39
[10] SERKOV FN, 1970, ELECTROPHYSIOLOGY

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