FAILURE OF COPOLYMER-I TO INHIBIT THE HUMAN T-CELL RESPONSE TO MYELIN BASIC-PROTEIN

被引：19

作者：

BURNS, J ^{[1
]}

LITTLEFIELD, K ^{[1
]}

机构：

[1] UNIV UTAH,DEPT NEUROL,SALT LAKE CITY,UT 84112

来源：

NEUROLOGY | 1991年 / 41卷 / 08期

关键词：

D O I：

10.1212/WNL.41.8.1317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In clinical trials, copolymer I (Cop 1) appears to reduce the number of exacerbations in early relapsing-remitting multiple sclerosis. The mechanism of this effect is uncertain, but Cop 1 also reduces the severity of experimental allergic encephalomyelitis and inhibits the response of murine myelin basic protein (MBP)-specific T cells. We tested MBP-specific T-cell lines and clones from four subjects to determine whether Cop 1 also limits the human response to MBP. We found no inhibition by Cop 1 of the human T-cell response to MBP.

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页码：1317 / 1319

页数：3

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