PREPARATION OF BIODEGRADABLE MICROSPHERES AND MICROCAPSULES .2. POLYACTIDES AND RELATED POLYESTERS

被引：191

作者：

ARSHADY, R

机构：

[1] Departmemt of Chemistry, Imperial College of Science, Technology and Medicine, London

来源：

JOURNAL OF CONTROLLED RELEASE | 1991年 / 17卷 / 01期

关键词：

MICROSPHERE; MICROCAPSULE; BIODEGRADABLE POLYESTER; PARTICLE SIZE CONTROL; RELEASE CONTROL; SOLVENT EVAPORATION; SOLVENT EXTRACTION; SOLVENT SELECTION;

D O I：

10.1016/0168-3659(91)90126-X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review presents a general survey of the manufacturing methods of microspheres and microcapsules based on biodegradable polyesters, including polylactides, polyglycolide, polyhydroxybutyrate, polycaprolactone, polycarbonates and related copolymers. Various procedures and modification of solvent evaporation and solvent extraction techniques employed for these preparations are described. The effects of process parameters (e.g. polymer concentration, stirring speed and mode of solvent removal) on microsphere/microcapsule characteristics (e.g. particle size, porosity and release pattern) are also outlined.

引用

页码：1 / 21

页数：21

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